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Added 40 mins ago
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Alexion Pharmaceuticals, Inc.

Non-Clinical Toxicology Manager

Mississauga, ON, Canada

Full-time

Apply About employer

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Job details

Job type: Full-time
Experience: Minimum of 3-5 years of experience as a toxicology study director/monitor in pharma, biotech or CRO setting,
Posting language: English
Posted: Sep 19, 2026

Original job description

Location: Mississauga, ON (hybrid 3x a week)

When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our outstanding and ambitious world.

Introduction to the role

Join us at Alexion, AstraZeneca's Rare Disease division, as a Non-Clinical Manager. You will be a key member of the non-clinical team in this role. You will collaborate with the global project team, regulatory affairs, and clinical team as an expert in early drug development. Your key accountabilities will be to support our programs, bringing your scientific and technical expertise to the teams to ensure the success of preclinical development programs. The right candidate will be a critical thinker that brings technical expertise and enthusiasm for the company along with a deep scientific knowledge. In collaboration with our partners (CROs), you will oversee the design, implementation, management and reporting of pre-clinical studies: pharmacokinetics, general toxicology, reproduction toxicology, genotoxicity, carcinogenicity, safety pharmacology.

What You’ll Do

Assist in selecting partners to conduct studies with regards to the expertise, quality, cost and time aspects,
Act as the privileged contact with CROs for contracts, invoices, study setup, monitoring, onsite visit and reporting,
Identify and resolve scientific, technical, logistical or quality issues related to studies,
Ensure that studies align with regulatory and quality requirements,
Review, analyze and interpret the data, coordinate report review and finalization with highest quality standards,
Summarize, communicate and promote results to the project teams and management,
Coordinate activities with other departments (finances, CMC, bioanalysis, regulatory…),
Closely monitor technological and regulatory developments in your field of expertise.

Requirements

PharmD, VetD, master’s degree in biology, animal sciences, toxicology or related fields, or Bachelors with relevant experience
Minimum of 3-5 years of experience as a toxicology study director/monitor in pharma, biotech or CRO setting,
Expertise in management of nonclinical studies, including the fundamentals of Good Laboratory Practices (GLP) and data interpretation of nonclinical studies,
Ensure successful study execution within allocated budgets and timelines,
Good interpersonal and communication skills with ability to relate to both internal and external collaborators,
Good organizational, planning, and project management skills, attention to detail,
Good English proficiency (written and spoken), as it is a daily working

Great People want to Work with us! Find out why:

GTAA Top Employer Award for 10 years
Top 100 Employers Award
Canada’s Most Admired Corporate Culture
Learn more about working with us in Canada
View our YouTube channel

At Alexion, you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients' lives.

Ready to lead and encourage? Apply now and take the first step towards a fulfilling career at Alexion, AstraZeneca Rare Disease.

⠀

Annual base salary for this position ranges from 110,999.20 to 145,686.45.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.

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More about this job

Responsibilities

The Non-Clinical Toxicology Manager will oversee the design, implementation, and reporting of preclinical studies in collaboration with CRO partners. They will also act as a key scientific expert, ensuring study alignment with regulatory requirements and communicating results to project teams.

Requirements

Candidates must hold a PharmD, VetD, or a master's degree in a relevant scientific field, or a bachelor's degree with equivalent experience. A minimum of 3-5 years of experience as a toxicology study director or monitor in a pharma, biotech, or CRO setting is required.

Skills

Toxicology
Pharmacokinetics
Preclinical Development
Good Laboratory Practices
Regulatory Affairs
Project Management
Data Interpretation
Study Monitoring
Scientific Communication
CRO Management
Safety Pharmacology
Genotoxicity
Carcinogenicity
Reproduction Toxicology
Technical Writing
Critical Thinking

Benefits

Flex Benefits
Retirement Savings Program
4 Weeks Paid Vacation
Personal Days
Variable Pay Bonus
Short Term Incentive
Equity-based Long-term Incentive Program

Visa sponsorship

Not detected in the job text

Keywords

Toxicology
Pharmacokinetics
Preclinical
GLP
CRO
Regulatory Affairs
Drug Development
Safety Pharmacology
Genotoxicity
Carcinogenicity
Reproduction Toxicology
Study Director
Biotechnology
Pharmaceuticals
Project Management
Data Analysis
Compliance
Quality Assurance
Rare Disease
AstraZeneca
Alexion
Scientific Research
Clinical Teams
CMC
Bioanalysis

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