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Altasciences

Senior Research Scientist, Method Development (LC-MS)

Laval, QC, Canada

Full-time

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Job details

Job type: Full-time
Experience: Typically 5-8+ years of relevant experience in LC-MS/MS bioanalysis, with demonstrated experience independently leading bioanalytical method development projects.
Posting language: English
Posted: Sep 18, 2026

Original job description

About The Role

We are seeking a highly motivated and experienced Senior Research Scientist with strong expertise in bioanalytical mass spectrometry to join our Method Development team. The successful candidate will lead the development and optimization of regulatory-ready bioanalytical methods using liquid chromatography-mass spectrometry (LC-MS/MS) for a variety of therapeutic modalities, including small molecules, peptides, biologics, biomarkers, and oligonucleotides.

What You’ll Do Here

Develop and optimize robust bioanalytical methods using LC-MS/MS in compliance with regulatory standards.
Perform and oversee sample preparation, analysis, and data interpretation while meeting project timelines and quality expectations.
Investigate and resolve complex bioanalytical challenges through systematic troubleshooting, experimental design, and root-cause assessment.
Participate in client discussions and scientific meetings, communicating method development strategies, analytical results, and technical recommendations.
Prepare, review, and approve method development reports, SOPs, and other technical documentation as required.
Collaborate with validation and operational teams to support successful method transfer and implementation.
Stay current with advancements in LC-MS technologies and best practices to support continuous improvement.
Adhere to Health and Safety protocols, including personal protective practices and laboratory upkeep.

What You’ll Need to Succeed

Master’s or Ph.D. in Biochemistry, Chemistry, Analytical Chemistry, or a related discipline; a Bachelor’s degree with significant relevant experience may also be considered.
Typically 5-8+ years of relevant experience in LC-MS/MS bioanalysis, with demonstrated experience independently leading bioanalytical method development projects.
Experience in sample preparation techniques appropriate to the analyte type (e.g., protein precipitation, solid-phase extraction, immunoaffinity-based approaches, enzymatic digestion).
Strong scientific writing, communication, and presentation skills, with the ability to effectively communicate complex technical concepts to both scientific and non-scientific stakeholders.

Altasciences strives to provide a French work environment for its employees in Quebec. Altasciences has taken all reasonable measures to avoid imposing the above language requirement. This requirement is essential for the position of Senior Research Scientist, Method development (LCMS) in particular, but without limitation, for the following reason(s):

The requirement to have study protocols read and documented in English as required by industry regulatory agencies

What We Offer

Altasciences offers a wide variety of benefits to help our employees live healthy and fulfilling lives both at and outside of work.

Altasciences’ Benefits Package Includes:

Health/Dental/Vision Insurance Plans
401(k)/RRSP with Employer Match
Paid Vacation and Holidays
Paid Sick and Bereavement Leave
Employee Assistance & Telehealth Program

Altasciences’ Incentive Programs Include:

Training & Development Programs
Employee Referral Bonus Program
Annual Performance Reviews

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More about this job

Responsibilities

The Senior Research Scientist will lead the development and optimization of robust bioanalytical methods using LC-MS/MS to support various therapeutic modalities. They will also oversee sample preparation, interpret complex data, and ensure all documentation complies with regulatory standards.

Requirements

Candidates must hold a Master's or Ph.D. in a relevant scientific discipline with 5-8+ years of experience in LC-MS/MS bioanalysis. Strong expertise in sample preparation techniques and the ability to communicate complex technical concepts to stakeholders are essential.

Skills

LC-MS/MS
Bioanalysis
Method development
Sample preparation
Protein precipitation
Solid-phase extraction
Immunoaffinity
Enzymatic digestion
Data interpretation
Troubleshooting
Regulatory compliance
Scientific writing
Technical documentation
Method transfer
Analytical chemistry
Biochemistry

Benefits

Health insurance
Dental insurance
Vision insurance
401(k)
RRSP
Employer match
Paid vacation
Paid holidays
Paid sick leave
Bereavement leave
Employee assistance program
Telehealth program
Training and development programs
Employee referral bonus program

Visa sponsorship

Not detected in the job text

Keywords

LC-MS/MS
Bioanalytical
Mass spectrometry
Small molecules
Peptides
Biologics
Biomarkers
Oligonucleotides
Method development
Sample preparation
Protein precipitation
Solid-phase extraction
Immunoaffinity
Enzymatic digestion
Regulatory standards
SOPs
Analytical chemistry
Biochemistry
Troubleshooting
Method transfer
Data interpretation
Scientific writing
Laboratory upkeep
Health and safety protocols

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