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Added 1 day ago
Associate Director - Decision Science
AstraZeneca
Mississauga, ON · Canada - Mississauga
Full-time
…elevate commercial strategy, and improve outcomes for people living with rare diseases? In this role, you will turn sophisticated, de-identified healthcare data into decisions that sharpen…
Added 11 days ago
Senior Specialist, National Sales Enablement
IG Wealth Management
ON · Ontario, Canada
Full-time
Provide on-the-ground support for National Sales leadership, including meeting guests, coordinating executive meetings and supporting other in-office needs.
Added 2 days ago
Director, Advocacy for Indigenous Women
Downtown Eastside Women s Centre
Vancouver, BC
$103,721 to $120,192.8 CAD / year
Full-time
The Downtown Eastside Women’s Centre (DEWC) exists to support and empower women and children, living in extreme poverty in the Downtown Eastside of Vancouver, who are particularly…
Added 2 days ago
Full Time Recreation Therapist
Cogir Senior Living
Calgary, AB · McKenzie Towne Retirement
Full-time
To escalate resident or family complaints to the Executive Director if beyond the scope of Active Living Manager;
Added 2 days ago
Sous Chef
Cogir Senior Living
BC · Hollyburn House
Full-time
Cogir Senior Living manages retirement residences across the country. We offer a range of senior living options including independent living, assisted living and memory care.
Added 1 day ago
Full Time Recreation Therapist
COGIR Real Estate
Calgary, AB
Full-time
To escalate resident or family complaints to the Executive Director if beyond the scope of Active Living Manager;
Added 2 days ago
Director, Engineering Performance & AI Metrics
Canadian Tire Corporation
Toronto, ON
Full-time
…Triangle Learning Academy, Canadian Tire Profit Sharing, and retirement and savings programs for eligible employees. As part of our enhanced flex benefits program, we offer mental health…
Added 2 days ago
DIRECTOR - TECHNOLOGY INFRASTRUCTURE & OPERATIONS - HYBRID
Green Shield Canada
Windsor, ON
The Director, Infrastructure & Operations is accountable for the foundational platforms that support GreenShield's business and customer-facing services. The role provides strategic…
Added 2 days ago
Administrative Assistant
Royal Bank of Canada
Vancouver, BC
Full-time
…Family Office Services (VP of Will and Estate Consultants, Director Will & Estate Planning , VP of Financial Planning Western Region, and Senior Director, Retirement…
Added 2 days ago
Administrative Assistant
RBC
Vancouver, BC
Full-time
…Family Office Services (VP of Will and Estate Consultants, Director Will & Estate Planning , VP of Financial Planning Western Region, and Senior Director, Retirement…
Added 2 days ago
Director, Digital Security Credential & Data Intelligence
RBC
Toronto, ON · Montreal, QC
Full-time
As Director, Digital Security Credential & Data Intelligence, you will own the credential lifecycle for RBC's digital clients (creation, recovery, rotation, retirement), plus the…
Added 1 day ago
Director, Digital Security Credential & Data Intelligence- EN
RBC
Montreal, QC
Full-time
As Director, Digital Security Credential & Data Intelligence, you will own the credential lifecycle for RBC's digital clients (creation, recovery, rotation, retirement), plus the…
Added 1 day ago
Active Living Aide - Part Time
COGIR Real Estate
Ottawa, ON
Part-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 1 day ago
Sous Chef
COGIR Real Estate
Vancouver, BC
Full-time
Cogir Senior Living manages retirement residences across the country. We offer a range of senior living options including independent living, assisted living and memory care.
Added 2 days ago
Director, Digital Security Credential & Data Intelligence
Royal Bank of Canada
Montreal, QC
Full-time
As Director, Digital Security Credential & Data Intelligence, you will own the credential lifecycle for RBC's digital clients (creation, recovery, rotation, retirement), plus the…
Added 2 days ago
Active Living Aide - Part Time
Cogir Senior Living
Ottawa, ON · Prince of Wales
Part-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 2 days ago
Active Living Aide - Full Time
COGIR Real Estate
Ottawa, ON
Full-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 2 days ago
Active Living Aide - Part Time
COGIR Real Estate
Ottawa, ON
Part-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 3 days ago
Active Living Aide - Part Time
Cogir Senior Living
Ottawa, ON · Valley Stream
Part-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 3 days ago
Active Living Aide - Full Time
Cogir Senior Living
Ottawa, ON · Valley Stream
Full-time
Assist in the planning, organization and implementation of meaningful programs for the residents, in collaboration with the Active Living Manager & Executive Director;
Added 3 days ago
Kitchen Utility Worker
Atria Retirement Canada - Victorian
Colwood, BC
Full-time
Work closely with the Director of Culinary Services and/or Executive Director to keep residents satisfied with food and dining programs.
Added 3 days ago
Executive Director- Retirement Operations
COGIR Real Estate
Surrey, BC
Full-time
Seeking an Executive Director with strong operations leadership experience in hospitality. You'll oversee general management of our retirement residence, delivering a superior "More Living"…
Added 4 days ago
Executive Director- Retirement Operations
Cogir Senior Living
Surrey, BC · Fleetwood Villa
Full-time
Seeking an Executive Director with strong operations leadership experience in hospitality. You'll oversee general management of our retirement residence, delivering a superior "More Living"…
Added 3 days ago
Manager, Finance
WP Osborne Executive Search Inc.
Toronto, ON · Greater Toronto Area, Canada
Full-time
Starlight Investments, in conjunction with WP Osborne Executive Search, is seeking a Manager, Finance, to join its Portfolio Finance team.
Added 4 days ago
Investment Analyst, Stewardship, Publications
Minnesota Direct Care and Treatment
Saint-Paul, NB · St.-Paul, NB
Full-time
Telework Eligible: Yes, with weekly anchor days required. This is subject to change at the discretion of the SBI Executive Director.

AstraZeneca

Associate Director - Decision Science

Mississauga, ON, Canada
Canada - Mississauga, Canada

Job type: Full-time
Apply by: Sep 21, 2026
Posting language: English
Posted: Sep 19, 2026

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Original job description

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Introduction to role:

Are you ready to bring publication-grade statistical difficulty and AI-native analytics together to uncover hidden patients, elevate commercial strategy, and improve outcomes for people living with rare diseases? In this role, you will turn sophisticated, de-identified healthcare data into decisions that sharpen field execution, optimize investment, and ultimately reach those who need therapies most.

You will join a fast-moving analytics team that pairs deep statistical expertise with modern machine learning and Snowflake Cortex AI to accelerate model development without compromising interpretability or compliance. From patient identification and adherence prediction to marketing effectiveness and causal impact, you will deliver models that are trusted by leaders and used by teams every day. Do you thrive at the intersection of analytical depth and real-world impact?

Accountabilities:

Statistical Authority: Act as the go-to guide to set analytical standards across hypothesis testing, regression, inference, and experimental design; ensure outputs meet publication-grade rigor with clear assumptions, diagnostics, and power.
Predictive Modeling: Design, validate, and deploy models using XGBoost, LightGBM, Random Forest, SVM, neural networks, and ensembles; address class imbalance with robust evaluation and calibration to drive precise commercial actions.
Time-to-Event Analytics: Build survival models (Cox, AFT, competing risks) to predict adherence, discontinuation, and patient lifetime value that inform proactive interventions.
Forecasting: Create and maintain ensemble time-series frameworks (ARIMA, Prophet, exponential smoothing, gradient-boosted) to guide demand planning, revenue scenarios, and launch-readiness decisions.
Causal Impact: Design A/B tests and apply quasi-experimental methods (DiD, PSM, synthetic control, IV, RDD) to quantify the true effect of commercial initiatives on prescribing and patient outcomes.
Marketing Mix Optimization: Develop Bayesian MMM to estimate channel-level return on investment and response curves; recommend promotional reallocations that improve impact across personal and non-personal channels.
Next-Best-Action Engines: Build and refine HCP-level recommendation systems using contextual bandits, collaborative filtering, and reinforcement learning; integrate daily actions into Veeva CRM.
Patient Identification: Train supervised classifiers on claims, labs, and specialty pharmacy data to prioritize likely undiagnosed patients and direct field resources where they matter most.
Adherence and Retention: Deploy models that detect early risk signals from dispense intervals, hub interactions, and scheduling patterns to reduce discontinuation.
Segmentation and Targeting: Construct HCP and patient segments using clustering and NLP-enriched profiles to focus engagement and tailor messaging.
Competitive Intelligence: Create real-time switching surveillance models from claims and formulary data to anticipate market dynamics and inform agile responses.
Agent-Assisted Development: Use Snowflake Cortex AI and AI coding agents to speed prototyping and feature engineering while retaining full human-led statistical validation.
Validation and Hallucination Detection: Build guardrails and evaluation suites that stress-test agent outputs, catch plausible-but-wrong reasoning, and prevent flawed insights from reaching decisions.
Agent Tuning and Evaluation: Design domain-specific prompts, benchmarks, and feedback loops to continuously improve agent analytical performance.
HIPAA-Compliant Data Operations: Work exclusively with de-identified patient-level data; implement minimum-necessary access and maintain re-identification risk assessments.
Model Guardrails and Interpretability: Implement bias detection, fairness audits, SHAP/LIME, drift monitoring, and validation gates; maintain end-to-end audit trails aligned to FDA, REMS, GDPR, SOC2, 21 CFR Part 11, and enterprise AI governance.
Cross-Functional Partnership: Translate sophisticated statistics into clear recommendations for Brand, Market Access, Patient Services, and Field teams; influence senior leaders with evidence that drives action.
Documentation and Enablement: Create meticulous documentation, code reviews, and trainings that set the standard across the analytics community and ensure sustainable, repeatable excellence.

Crucial Skills/Experience:

Education: Master’s or PhD in Statistics, Biostatistics, Data Science, Econometrics, Applied Mathematics, or a related quantitative field.
Experience: Minimum 7+ years in data science, applied statistics, or quantitative commercial analytics with a track record of deploying production-grade models in healthcare or life sciences.
Statistical Expertise: Expert-level proficiency in hypothesis testing, regression analysis (linear, logistic, mixed-effects, regularized), ANOVA, survival analysis, Bayesian inference, experimental design, power analysis, significance testing, and multiple comparison corrections. Deep understanding of when statistical methods apply, when they break down, and how to adapt for small-population rare disease contexts.
Predictive Analytics & ML: Proficiency in XGBoost, LightGBM, Random Forest, SVM, ensemble methods, neural networks, and time-series forecasting with thorough validation (cross-validation, precision-recall, ROC/AUC, calibration).
Programming & Libraries: Expert-level Python (scikit-learn, XGBoost, LightGBM, statsmodels, lifelines, scipy.stats, PyMC, CausalML, DoWhy, SHAP, PyTorch) and SQL. Proficiency with Jupyter, Git, and CI/CD integration for model deployment.
Data Platform: Proficiency with Snowflake (Snowpark Python, Snowpark Container Services, Cortex AI), Spark/PySpark, and MLflow or equivalent experiment tracking and model registry tools.
Marketing Mix & NBA: Hands-on experience building Bayesian MMM (PyMC, LightweightMMM, Robyn) and Next-Best-Action recommendation engines for pharmaceutical promotional optimization.
AI/LLM Proficiency: Experience with AI coding agents (Cortex AI, Claude Code, Copilot) for analytical development. Ability to critically evaluate agent-generated code and identify incorrect statistical reasoning.
HIPAA & Guardrails: Solid understanding of HIPAA de-identification standards, model explainability frameworks (SHAP, LIME), bias detection, and compliance with regulated healthcare data environments.
Communication: Ability to translate sophisticated statistical findings into actionable recommendations for non-technical commercial partners and senior leadership.

Desirable Skills/Experience:

Rare Disease & Specialty Pharma: Experience in rare disease or specialty pharma analytics - small-population modeling, patient identification, specialty pharmacy data, hub/PSP, REMS-related data, and high-value-per-patient environments.
Industry Data Sources: Hands-on experience with Komodo Health (open and closed claims), IQVIA (Symphony, NPA, DDD), Veeva CRM, MMIT, Model N, specialty pharmacy dispense data, and EMR/EHR data.
NLP & Deep Learning: Experience with NLP (topic modeling, NER, embeddings, text classification) and neural network architectures (RNNs, LSTMs, transformers) for healthcare analytics applications.
LLM Evaluation: Experience with RLHF concepts, benchmark design, systematic prompt evaluation, and agent reasoning quality assessment.
Visualization: Proficiency with PowerBI, Tableau, or Qlik for executive-facing dashboards and self-service reporting.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Great People want to Work with us! Find out why:

Why AstraZeneca:

Here you will use cutting-edge data platforms and modern AI methods to tackle meaningful problems for under-served patient populations, supported by teammates who value curiosity, integrity, and momentum. You will feel the energy of a nimble, entrepreneurial environment with the reach of a global biopharma, collaborating across disciplines to turn analytics into confident decisions that shape markets and care pathways. We value kindness alongside ambition, and we invest in growth that deepens both your technical mastery and your understanding of patients’ lived experiences - so your contribution scales from a single model to lasting impact.

Call to Action:

If you are ready to pair statistical excellence with AI-native speed to create sharper decisions and better outcomes, seize this opportunity to lead from the front and make your impact.

At Alexion, you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients' lives.

Ready to lead and inspire? Apply now and take the first step towards a fulfilling career at Alexion, AstraZeneca Rare Disease.

⠀

Annual base salary for this position ranges from 134,708.00 to 176,804.25.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.

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More about this job

Responsibilities

The Associate Director will lead the development of advanced predictive models and statistical frameworks to optimize commercial strategy and patient outcomes in rare diseases. They will partner with cross-functional teams to translate complex analytical insights into actionable business decisions while ensuring compliance with healthcare regulations.

Requirements

Candidates must hold a Master’s or PhD in a quantitative field and possess at least 7 years of experience in data science or applied statistics within the life sciences industry. Proficiency in Python, SQL, and advanced statistical modeling techniques is essential for this role.

Skills

Statistics
Machine Learning
Predictive Modeling
Python
SQL
Snowflake
Bayesian Inference
Causal Impact
Marketing Mix Optimization
Data Science
Survival Analysis
Forecasting
NLP
Data Governance
Pharmaceutical Analytics
Communication

Benefits

Flex Benefits
Retirement Savings Program
4 Weeks Paid Vacation
Annual Personal Days
Variable Pay Bonus
Short Term Incentive
Equity-based Long-term Incentive Program

Visa sponsorship

Not detected in the job text

Keywords

Decision Science
Statistics
Machine Learning
Snowflake Cortex AI
XGBoost
LightGBM
Bayesian MMM
Next-Best-Action
Survival Analysis
Causal Inference
Python
SQL
HIPAA
GDPR
Rare Disease
Pharmaceuticals
Predictive Analytics
Data Governance
SHAP
LIME
Veeva CRM
Komodo Health
IQVIA
Time-series Forecasting
Neural Networks
Clustering
NLP
Biostatistics
Econometrics
Applied Mathematics

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