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AstraZeneca

Senior Scientist, Imaging (12 Month Contract)

Hamilton, ON, Canada
Canada – Hamilton – Longwood Road South, Canada

Full-time

Apply on astrazeneca.wd3.myworkdayjobs.com About employer

Applications open in a new tab.

Job details

Job type: Full-time
Apply by: Dec 1, 2026
Posting language: English
Posted: Nov 10, 2026

Original job description

Senior Scientist, Imaging

Duration: 12 months

Location: Hamilton, ON

Onsite 5 days/ week

Description:

Fusion Pharmaceuticals, part of the AstraZeneca Group, is redefining precision oncology with next‑generation radio conjugates that deliver powerful alpha‑emitting payloads directly to tumors. Our pipeline spans multiple first‑in‑class programs - backed by a GMP‑compliant, brand new radiopharmaceutical facility in Hamilton, we’re turning groundbreaking science into real‑world impact for patients. Join us at the forefront of radio pharma innovation and be part of turning breakthrough science into meaningful outcomes for patients - come build what’s next with us!

The Role:

As Sr. Scientist, Imaging, this role is for an experienced preclinical imaging scientist to join the In Vivo Pharmacology team within AstraZeneca’s Radioconjugate Discovery Group. The successful candidate will provide strategic and technical expertise in the conception, design, execution and interpretation of preclinical imaging studies. A critical component will be the integration of nuclear imaging methodologies with pharmacology and ex vivo readouts to provide decision-enabling insights across Discovery activities including candidate screening and selection, mechanism of action, dosimetry, and biomarker discovery.

What you’ll do

Design, conduct, and analyze imaging-based biodistribution and mechanistic studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest) to enable decision-making data packages for go/no-go decisions. Perform reconstruction and quantification of multimodal imaging data
Drive the development and implementation of imaging-based methods to explore dosimetry and PK/PD relationships as they relate to mechanism of action across our therapeutic pipeline. Integrate results with ex vivo tissue biodistribution and efficacy studies
Build strong partnerships with cross-functional experts, align collaborators and clearly communicate plans and results to teams and governance
Develop and expand internal preclinical imaging capabilities and spearhead the incorporation of nuclear imaging modalities into AstraZeneca’s Radioconjugate Discovery experimental workflow.
Align nuclear medicine imaging protocols, including review of parameters for QC, image acquisition and reconstruction, radiation dose determination, and protocol dose management
Oversee the maintenance, calibration, and operation of innovative PET/SPECT/CT/MRI/Optical imaging equipment
Mentor and train junior scientists on image acquisition, reconstruction, and analysis
Produce high quality and well documented data with strong attention to detail
Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges
Other duties as required

Essential for the role

MSc or Ph. D (Biochemistry, Biology, Immunology, Biomedical Engineering, Medical physics, Molecular/Cell Biology or related field)
3–6+ years of hands-on preclinical in vivo imaging in mouse models, demonstrating expertise in PET/SPECT and at least one of MRI or CT
Experience with in vivo mouse solid tumor models including IV injections, tumor implantation and tissue collections
Proficiency with analysis tools (PMOD, VivoQuant, 3D Slicer, Amide) and scripting (Python/MATLAB/R) for automation and reproducibility
Expertise with the operation of nuclear imaging equipment including software image reconstruction, analysis, and quantification of nuclear imaging data
Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment

Dedicated to finding practical solutions and works well with others in a multi-disciplinary setting, with the ability to communicate with colleagues at all levels

Experience with the safe handling of radioactive and biohazardous materials

Desirable for the role

Theranostic strategy experience and preclinical dosimetry modeling
Proficiency in quantitative image analysis and statistics and integration with ex vivo and PK/PD datasets
Experience evaluating radioconjugates in solid tumors (antibody-, peptide-, or small-molecule–based), including isotope/chelator selection and labeling parameters impacting in vivo behavior.
Biotech or pharmaceutical experience is an asset

Great People want to Work with us! Find out why:

Are you interested in working at AZ, apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com.

⠀

Annual base salary for this position ranges from 108,713.60 to 142,686.60.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.

Apply on astrazeneca.wd3.myworkdayjobs.com About employer

More about this job

Responsibilities

Design, conduct, reconstruct, and analyze preclinical imaging studies of radiopharmaceuticals in rodent disease models, integrating imaging results with ex vivo biodistribution, efficacy, and pharmacology data to inform research decisions. Develop imaging methods and capabilities, oversee imaging equipment and protocols, and collaborate with teams while mentoring junior scientists.

Requirements

Requires an MSc or PhD in a relevant life science, biomedical engineering, or medical physics field, plus 3–6+ years of hands-on preclinical imaging experience with PET/SPECT and at least one of MRI or CT. Candidates must have experience with mouse tumor models, imaging equipment and analysis software, scripting, and safe handling of radioactive and biohazardous materials.

Skills

Preclinical In Vivo Imaging
PET/SPECT Imaging
MRI/CT Imaging
Mouse Tumor Models
Radiopharmaceutical Biodistribution
Image Reconstruction and Quantification
PMOD
VivoQuant
3D Slicer
Amide
Python
MATLAB
R
Preclinical Dosimetry
Radioactive Material Handling
Cross-Functional Collaboration

Benefits

Contract Benefits Program

Visa sponsorship

Not detected in the job text

Keywords

Radioconjugates
Radiopharmaceuticals
Preclinical Imaging
In Vivo Pharmacology
PET
SPECT
MRI
CT
Optical Imaging
Biodistribution
Mechanism of Action
Dosimetry
PK/PD
Biomarker Discovery
Solid Tumor Models
Ex Vivo Tissue Analysis
Image Reconstruction
Image Quantification
PMOD
VivoQuant
3D Slicer
Amide
Python
MATLAB
R
Radiation Dose Management
Radioactive Material Handling
Theranostics
Isotope and Chelator Selection
GMP-Compliant Facility

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Jobs in Canada