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Added 2 mins ago
Senior Risk Manager
Turner & Townsend
Vancouver, BC · Calgary, Canada
Full-time
Ensure the delivery of best practice risk management activities and report to the Director of Risk Management and Head of Department.
Added 2 mins ago
Senior Risk Manager
Turner & Townsend
AB · Calgary, Canada
Full-time
Ensure the delivery of best practice risk management activities and report to the Director of Risk Management and Head of Department.
Added 15 mins ago
Director, Project Controls EPCM
Worley
AB · Edmonton, AB
Full-time
…consulting, engineering, procurement and construction across the project lifecycle, with services extending through to operations and decommissioning. Leveraging extensive experience and…
Added 15 mins ago
Director, Business Development & Member Engagement
Life Sciences Ontario
Toronto, ON · Greater Toronto Area, Canada
Full-time
Reporting directly to the President & CEO, the Director, Business Development & Member Engagement will lead the growth of LSO's membership, sponsorship and strategic partnership portfolio.…
Added 15 mins ago
Director, Business Intelligence & Category Management
Analyticsmart
Toronto, ON
Full-time
…comfortable moving between a client strategy discussion, a data delivery issue, and a category insight…
Added 46 mins ago
Director of Corporate Services
Grey Bruce Public Health
Owen Sound, ON
Full-time
The Director, Corporate Services is responsible for the effective leadership of the Corporate Services
Added 46 mins ago
Manager, Community Safety Wellbeing & Project Management
Toronto Community Housing
Toronto, ON · North York, ON
Full-time
Reporting to the Senior Director, Community Safety Unit, the Manager, CSWB Implementation and Project Management provides disciplined implementation, project-management and coordination…
Added 46 mins ago
Business Analyst
Government of Newfoundland and Labrador
St. John's, NL
$74,093 to $96,321 CAD / year
Full-time
…directly accountable for the efficient and effective development, delivery, and management of functional aspects of the PeopleSoft Human Resource Management System (HRMS). This includes…
Added 46 mins ago
Director, Operational Planning
York Region (The Regional Municipality of York)
Newmarket, ON
$168,725 to $198,450 CAD / year
Full-time
…implementation of the Paramedic & Seniors Services capital planning and delivery (asset management plans and facility maintenance) in consultation with Property Services; overseeing all…
Added 46 mins ago
Director, Facilities & Building Operations
Simon Fraser University
Burnaby, BC
Full-time
The Director, Facilities and Building Operations, provides senior operational and strategic leadership for the planning, stewardship, renewal, and effective use of SFU Libraries'…
Added 47 mins ago
Administrative Assistant II, Community Support Services - Full-time
VON Canada (Ontario)
London, ON
$24.18 to $25.69 CAD / hour
Full-time
The Administrative Assistant II provides administrative support to the Director of Home & Community Care and oversees office administration for the corresponding District maintaining a high…
Added 1 hour ago
Supplier Quality Engineer
Jamesway
Cambridge, ON
$70,000 to $80,000 CAD / year
Full-time
Reporting to the Quality Director, the Supplier Quality Engineer is responsible for leading supplier quality development and performance improvement, and advanced quality planning across…
Added 1 hour ago
Associate Registrar and Director of Admissions
University of Manitoba
Winnipeg, MB
$80,965.47 to $145,737.84 CAD / year
Full-time
…solutions that improve efficiency, collaboration, and service…
Added 1 hour ago
Research & Policy Analyst - 1 Full-time, Permanent Position in Edmonton or Calgary
Health Sciences Association of Alberta
AB · Edmonton, AB
Full-time
Reporting to the Director, Engagement, you will conduct research and analysis across a range of healthcare, health policy, funding, service delivery, public policy, operational, and…
Added 1 hour ago
Associate Director - Lead Application Support Specialist, GED Support
RBC
Toronto, ON
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Manage and optimize application job scheduling, ensuring seamless execution of critical processes and supporting smooth deployments during project implementations
Added 1 hour ago
Engagement Manager
Greenlight Consulting
Toronto, ON
$110,000 to $130,000 CAD / year
5–8 years in a delivery, project management, or client-faci
Added 1 hour ago
Incubation Lab Administrator
University of British Columbia
Vancouver, BC · UBCV | University Services Building (USB)
$7,158.42 to $10,292.25 CAD / month
Full-time
This role will Design, plan, and lead the operation and service delivery of a university wide Incubation Lab research support program that enables faculty to advance application-level and…
Added 1 hour ago
Director of Franchise Development
Pizzaiolo The Pizza Maker's Pizza
Mississauga, ON
Full-time
The Director of Franchise Development will build and convert a qualified franchisee pipeline through active prospecting, disciplined candidate assessment and effective franchise sales.…
Added 2 hours ago
SAP Solutions Director
Pomerleau
Montreal, QC
Full-time
Working closely with internal teams that support major project delivery, as well as with relevant corporate functions, the Director ensures that the processes, data, and solutions supported…
Added 2 hours ago
Manager, Payroll
Ontario Health atHome
ON · Ontario, Canada
Full-time
…administrative functions for payroll systems. Reporting to the Director, Payroll, the Manager, Payroll collects and analyzes fiscal data and performs financial modeling including analysis…
Added 2 hours ago
Project Manager (Mining)
JobsMedia.io
Montreal, QC
Full-time
Our client, a recognized company in the mining sector, is looking for a Project Director to lead the planning, execution and delivery of large-scale mining projects, from the design phase…
Added 2 hours ago
Primary Care & Community Engagement Coordinator-Elgin OHT
St. Thomas Elgin General Hospital
St. Thomas, ON
$37.23 to $43.57 CAD / hour
Full-time
…and community awareness. Reporting to the Elgin OHT Executive Director, this temporary contract position will provide coordination, communications, engagement and project support for…
Added 2 hours ago
SAP Solutions Director
Pomerleau
Saint-Georges, QC · St-Georges, QC
Full-time
Working closely with internal teams that support major project delivery, as well as with relevant corporate functions, the Director ensures that the processes, data, and solutions supported…
Added 2 hours ago
SAP Solutions Director
Pomerleau
Quebec, QC
Full-time
Working closely with internal teams that support major project delivery, as well as with relevant corporate functions, the Director ensures that the processes, data, and solutions supported…
Added 2 hours ago
Manager, Community Safety Wellbeing & Project Management
Toronto Community Housing or Toronto Seniors Housing
Toronto, ON
Reporting to the Senior Director, Community Safety Unit, the Manager, CSWB Implementation and Project Management provides disciplined implementation, project-management and coordination…

Sitero LLC

Senior Director, Clinical Operations

Mississauga, ON, L4W 5L1, Canada

Job type: Full-time
Experience: 12+ years of clinical research experience, with at least 5 in a leadership role within a CRO or full-service sponsor environment
Working hours: 40 hours per week
Posting language: English
Posted: Sep 25, 2026

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Original job description

Sitero is an emerging leader in Clinical services and software solutions for the life sciences industry. We have experience and expertise in a diverse range of therapeutic areas and focus on innovative, technology-enabled solutions that allow our clients to focus on their core strengths. For early phase studies through Phase III clinical trials, our experienced team delivers high-touch services and technology to ensure the safety of all stakeholders across the clinical research community with an emphasis on ethics, compliance, and innovation.

Job Title: Senior Director, Clinical Operations

Location: Mississauga, Canada (Hybrid; 3X per week in office)

Function: Clinical Operations

We are seeking a strategic, hands-on Senior Director of Clinical Operations to serve as the operational backbone of Sitero's full-service CRO offering. This leader will own the end-to-end delivery of clinical programs across our client portfolio, set the standard for how Sitero executes trials, and build the infrastructure, talent, and processes that allow us to scale with quality.

You will be a working leader who shapes how Sitero operates every day - partnering closely with business development, regulatory, data management, and site engagement to deliver trials that sponsors trust and patients benefit from.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

Program Delivery

Accountable for the clinical execution of all full-service programs across phases I–IV, including oversight of CRAs, CTMs, and project management staff
Ensure delivery against timeline, budget, quality, and protocol adherence commitments across the portfolio
Serve as executive sponsor and escalation point for complex, high-risk, or high-value studies

Operational Infrastructure

Define and continuously refine Sitero's clinical operations SOPs, working practices, and quality standards
Build and maintain resourcing models, capacity planning frameworks, and performance metrics that give leadership real-time visibility into portfolio health
Lead the selection, implementation, and optimization of clinical systems (EDC, CTMS, eTMF, risk-based monitoring tools)

People Leadership

Recruit, develop, and retain a high-performing clinical operations team - CRAs, CTMs, Sr. and Project Directors
Build a culture of accountability, scientific curiosity, and client partnership
Establish clear career pathways and competency frameworks for the clin ops function

Client & Business Partnership

Partner with Business Development on proposals, bid defense meetings, and scope development - functioning as the clinical operations voice in business acquisition
Serve as a trusted senior contact for sponsor clients throughout engagement, from kickoff through closeout
Translate sponsor needs into operational plans that are realistic, risk-aware, and staffed to deliver

Quality & Compliance

Champion a risk-based monitoring philosophy and embed quality by design into every program
Ensure inspection readiness across all active studies; lead preparation for sponsor audits and regulatory inspections
Monitor and respond to emerging regulatory guidance (FDA, EMA, ICH E6 R3) and ensure organizational alignment

EDUCATION AND EXPERIENCE REQUIRED:

12+ years of clinical research experience, with at least 5 in a leadership role within a CRO or full-service sponsor environment
Deep expertise across trial phases (I–IV) and therapeutic areas; experience in complex or underserved populations is a plus
Demonstrated ability to build and scale clinical operations functions - not just manage existing ones
Track record of delivering multi-study portfolios on time and within budget while maintaining quality
Fluency in risk-based monitoring principles and modern clinical trial technology platforms
Strong commercial instincts - comfortable in BD settings, client-facing conversations, and budget negotiations
Exceptional communicator who can move between scientific, operational, and executive registers with ease

COMPENSATION & BENEFITS:

Sitero proudly offers an impressive compensation package and benefits, including a competitive salary, paid time off, and healthcare and retirement benefits.

EMPLOYMENT TYPE:

Full Time, Permanent

COMMITMENTS:

Standard Hours 40 hours per week, one hour lunch, Monday – Friday. Additional hours as needed.
3X per week working from our Mississauga office (Mon, Tues, Wed)
2X per week working from your home office remotely (Thurs, Fri)
Willing to work in shifts as and when needed.

DISCLAIMER:

Sitero is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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More about this job

Responsibilities

The Senior Director of Clinical Operations will oversee the end-to-end delivery of clinical programs, ensuring adherence to timelines, budgets, and quality standards. They will also build and refine operational infrastructure, lead the clinical operations team, and partner with business development to support client acquisition.

Requirements

Candidates must have at least 12 years of clinical research experience, including 5 years in a leadership role within a CRO or sponsor environment. Strong expertise in trial phases I-IV, risk-based monitoring, and clinical trial technology platforms is required.

Skills

Clinical operations
Project management
Risk-based monitoring
Strategic planning
Budget management
Regulatory compliance
Team leadership
Clinical trial management
SOP development
Capacity planning
Stakeholder management
Business development
Quality assurance
Clinical research
Vendor management
Data management

Benefits

Paid time off
Healthcare benefits
Retirement benefits

Visa sponsorship

Not detected in the job text

Keywords

Clinical Operations
CRO
Clinical Trials
Phase I-IV
EDC
CTMS
eTMF
Risk-based Monitoring
SOPs
Regulatory Affairs
FDA
EMA
ICH E6 R3
Project Management
Business Development
Life Sciences
Quality by Design
Inspection Readiness
Portfolio Management
Clinical Research Associate
Clinical Trial Manager
Strategic Leadership
Budgeting
Stakeholder Engagement
Capacity Planning
Performance Metrics
Therapeutic Areas
Compliance
Innovation
Clinical Services

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