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Synth-Med Biotechnology Inc.

Postdoctoral Researcher

Toronto, ON, Canada

Full-time

Apply About employer

Applications open in a new tab.

Job details

Job type: Full-time
Apply by: Dec 2, 2026
Posting language: English
Posted: Nov 2, 2026

Original job description

The position

Synth-Med Biotechnology Inc. is hiring a postdoctoral fellow to work in collaboration with Dr. Craig

Simmon’s lab on in vitro blood–brain barrier (BBB) models supporting Synth-Med’s CNS-directed

enzyme replacement therapy (ERT) and nanomedicine programs for lysosomal storage disorders.

The successful candidate you will be supporting our pre-clinical in-vitro testing of BBB crossing nano

carriers and help unveiling mechanistic processes of the technology.

This is a joint academic–industry role. You will be based in the Simmons Lab with access to its

microphysiological systems and stem cell infrastructure, and you will work closely with the Synth-Med

R&D team on program timelines and data packages.

What you'll do

Establish, validate, and maintain Transwell BBB models, including hiPSC-derived brain microvascular

endothelial cells in mono- and co-culture with astrocytes, pericytes, and/or neurons

Run barrier integrity and permeability assays (TEER, paracellular tracer flux, immunostaining for

junctional and transporter markers) and set acceptance criteria for study readouts

Design and execute transport studies on enzyme conjugates, shuttle-peptide and single-domain

antibody constructs, and nanoparticle carriers

Develop quantitative readouts of transcytosis and intracellular trafficking, and distinguish transport

from surface association

Adapt models to disease-relevant genotypes, including patient-derived or gene-edited iPSC lines

Analyze and present data to the Simmons Lab and to Synth-Med; contribute to internal reports,

regulatory-facing documentation, grant applications, and publications

Mentor graduate and undergraduate students working on related projects

Required

PhD in biomedical engineering, cell biology, neuroscience, pharmacology, or a related field

Hands-on experience building and running Transwell BBB models, with demonstrated command of

barrier integrity measurement and troubleshooting

Independent hiPSC culture experience.

Strong quantitative data analysis and a track record of peer-reviewed publication

Ability to work to project timelines in a collaborative, partly industry-facing setting

Preferred

Prior work on lysosomal storage disorders

Familiarity with nanoparticle or liposomal drug delivery and associated characterization methods

Experience with receptor-mediated transcytosis approaches

Microfluidic or organ-on-chip barrier models

Confocal and live-cell imaging, image quantification

Experience with electronic lab notebooks and structured documentation practices suitable for

regulatory submissions

Experience with co-culture assays and the practical problems that come with them - media

compatibility, seeding order, timing, and controls

What we offer

A project with a clear translational endpoint and a direct line to program decisions

Access to the Simmons Lab's microfabrication, imaging, and stem cell facilities, plus the wider

Toronto research ecosystem

Mentorship from both an academic PI and an industry R&D team, with exposure to preclinical

development and regulatory strategy

Support for conference travel and professional development

Publication rights on project outcomes, subject to standard IP review

How to apply

For your application:

please complete this form:

https://forms.office.com/r/YeY66vA3BE

and upload a cover letter and CV here:

https://synthmed.sharepoint.com/:f:/s/Hiring/IgDZWinpfd1vQ5ojXU6VO2t_AaXXf_W9wKPc0qEXZsLYwcU

Apply About employer

More about this job

Responsibilities

Establish and validate in vitro blood–brain barrier models, then use them to assess transport, permeability, and trafficking of enzyme conjugates, shuttle constructs, and nanoparticle carriers. Analyze and present findings, contribute to reports and publications, and mentor students in a collaborative academic–industry research program.

Requirements

A PhD in biomedical engineering, cell biology, neuroscience, pharmacology, or a related field is required, along with hands-on experience building and troubleshooting Transwell BBB models and independent hiPSC culture experience. Candidates should have strong quantitative analysis skills, peer-reviewed publications, and the ability to work collaboratively to project timelines.

Skills

Transwell BBB Models
hiPSC Culture
Barrier Integrity Assays
Permeability Assays
TEER Measurement
Transport Studies
Transcytosis Analysis
Quantitative Data Analysis
Cell Co-culture
Nanoparticle Drug Delivery
Confocal Imaging
Live-cell Imaging
Microfluidics
Scientific Writing
Student Mentoring

Benefits

Conference Travel Support
Professional Development Support

Visa sponsorship

Not detected in the job text

Keywords

Blood–Brain Barrier
Transwell Models
hiPSC-derived Brain Microvascular Endothelial Cells
TEER
Paracellular Tracer Flux
Immunostaining
Junctional Markers
Transporter Markers
Enzyme Replacement Therapy
Lysosomal Storage Disorders
Enzyme Conjugates
Shuttle Peptides
Single-domain Antibodies
Nanoparticle Carriers
Transcytosis
Intracellular Trafficking
Patient-derived iPSC Lines
Gene-edited iPSC Lines
Microphysiological Systems
Microfluidics
Organ-on-chip Models
Confocal Imaging
Live-cell Imaging
Co-culture Assays
Regulatory Documentation
Electronic Lab Notebooks
Preclinical Testing
CNS Drug Delivery

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